產(chǎn)品名稱：

活性氧AEM1，1030123-90-0

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實(shí)驗(yàn)！

Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation.1 AEM1 is an inhibitor of gene expression induced by nuclear erythroid 2-related factor 2 (Nrf2).2 It reduces Nrf2-dependent expression of the genes encoding superoxide dismutase 1 (SOD1), heme oxygenase 1 (HO-1), thioredoxin (Trx), glutamate-cysteine ligase (GCLM), and glutathione peroxidase 2 (GPX2), as well as decreases glutathione (GSH) content in A549 cells when used at 5 ?M. AEM1 enhances tert-butyl hydroperoxide-induced A549 cell death. In vivo, AEM1 (50 mg/kg) reduces tumor volume in an A549 mouse xenograft model.

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編輯：XAQYBIO HAO，2023年3月15日。