產(chǎn)品名稱：

活性氧BPTES，314045-39-1

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實驗！

BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1; IC50 = 3.3 μM) that drives the formation of inactive GLS1 tetramers.1 It is selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493 cells as well as induces cell death, increases the production of reactive oxygen species (ROS), and reduces ATP levels in hypoxic P493 cells.2 It also decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with UK 5099 (Item No. 16980) and/or etomoxir (Item No. 11969).3 In vivo, BPTES (12.5 mg/kg) reduces tumor volume in a P493 lymphoma mouse xenograft model.

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編輯：XAQYBIO HAO，2023年3月15日。