產(chǎn)品名稱：

Disulfiram-d20，1216403-88-1

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實(shí)驗(yàn)！

Disulfiram-d20 is intended for use as an internal standard for the quantification of disulfiram (Item No. 15303) by GC- or LC-MS. Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM).1 It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine.2 When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells.3,4 Disulfiram (at 250 nM) induces reactive oxygen species, activates JNK and p38 pathways, and inhibits NF-κB activity, which suppresses self-renewal in cancer stem cells.5,6

相關(guān)產(chǎn)品：

Quercetin-7-O-β-D-Glucopyranoside，491-50-9

Artesunate，88495-63-0，butanedioic acid

OBA-09，856095-68-6，2-(1,2-dioxopropoxy)-benzoic acid

編輯：XAQYBIO HAO，2023年3月15日。