產(chǎn)品名稱：

6-OHDA (hydrobromide)，636-00-0

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實(shí)驗(yàn)！

6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents.1 It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.2 Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.3 It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.4,5 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.5,6

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編輯：XAQYBIO HAO，2023年3月15日。