文獻(xiàn)：聚乳酸-聚乙二醇-聚乳酸三嵌段共聚物的降解性能

作者：高建文，廖凱榮，全大萍，盧澤儉

文獻(xiàn)鏈接：https://xueshu.baidu.com/usercenter/paper/show?paperid=a4591ddfa95725ae7a22a54d2fb088a9&site=xueshu_se

摘要：

A series of polylactic acid (PLA) - polyethylene glycol (PEG) - polylactic acid (PLA) triblock copolymers were prepared by ring opening polymerization of lactide using stannous octoate as initiator and polyethylene glycol as co initiator The influence of PEG molecular weight and propylene ester/PEG molar ratio on the hydrolysis behavior of copolymers was investigated by examining the changes in intrinsic viscosity [η], mass, and thermal behavior of copolymers during hydrolysis in physiological saline The results indicate that PEG blocks have a significant impact on the hydrolysis rate of copolymers When the molar ratio of propylene glycol/PEG is constant, the larger the molecular weight of PEG, the easier it is for the copolymer to hydrolyze; When the PEG block length is constant, the higher the molar ratio of propylene ester/PEG, the slower the hydrolysis rate of the copolymer

以辛酸亞錫為引發(fā)劑,聚乙二醇大分子為共引發(fā)劑進(jìn)行丙交酯開(kāi)環(huán)聚合制備了系列聚乳酸(PLA)-聚乙二醇(PEG)-聚乳酸(PLA)三嵌段共聚物.

從共聚物在生理鹽水中水解時(shí)特性黏度[η],質(zhì)量和熱行為的變化,考察了含PEG分子量和丙交酯/PEG摩爾投料比對(duì)共聚物水解行為的影響.

結(jié)果表明,PEG嵌段對(duì)共聚物的水解速度有重要影響.丙交酯/PEG摩爾投料比一定時(shí),PEG分子量越大,共聚物更容易水解;PEG嵌段長(zhǎng)度一定時(shí),丙交酯/PEG摩爾投料比越大,共聚物水解速度比較緩慢.

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mPEG-CH3

mPEG-tri-Glutamic Acid

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mPEG-PEI(25K)

mPEG-SBA

mPEG-PCL(3K)

mPEG-SS-C30

mPEG-PCL(10K)

mPEG-PCL(12K)

mPEG-Alkene

mPEG-DF

mPEG-DBCO

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