文獻(xiàn)：The role of MoS2 QDs coated with DSPE-PEG-TPP in the protection of protein secondary structure of the brain tissues in an Alzheimer's disease model

作者：Ohoud Abdulaziz Alamri a b, Safaa Qusti b, Maha Balgoon b, Abeer A. Ageeli c, F.A. Al-Marhaby d, Abeer M. Alosaimi e, Mohammed A. Jowhari f, Abdu Saeed g 

文獻(xiàn)鏈接：https://www.sciencedirect.com/science/article/abs/pii/S0141813023054211

摘要：

In a recent groundbreaking study [13], a pioneering approach was employed utilizing MoS2 QDs coated with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(poly-ethyleneglycol)-2000] (DPSE-PEG) linked with (3-carboxypropyl)triphenylphosphonium bromide (TPP). This innovative compound, recognized for its novel mitochondria-targeted properties, represents a potential therapeutic avenue for AD treatment [13]. The strategic DSPE-PEG-TPP coating layer serves as an essential interface, facilitating the attachment of MoS2 QDs to the mitochondria of microglia cells within brain tissues. Our present investigation builds upon this paradigm, delving into the intricate role of MoS2 coated with DSPE-PEG-TPP in safeguarding the protein secondary structure within brain tissues. Moreover, a comprehensive exploration of the impact of DSPE-PEG-TPP-MoS2 QDs treatment on a spectrum of biomarkers has been meticulously undertaken. Further elucidation of the methodology, detailed results, and an in-depth analysis can be found in subsequent sections, offering a comprehensive understanding of our study. This study sheds light on the role of MoS2 QD in the protection of the protein secondary structure of the brain tissues against AD etiology.

采用了一種開創(chuàng)性的方法，利用涂有1,2-二硬脂�；�-sn-甘油-3-磷乙醇胺-N-[氨基（聚乙二醇）-2000]（DPSE-PEG）的MoS2量子點(diǎn)，與（3-羧丙基）三苯基溴化鏻（TPP）連接。這種創(chuàng)新化合物因其新穎的線粒體靶向特性而受到認(rèn)可，代表了阿爾茨海默病的潛在治療途徑。戰(zhàn)略性的DSPE-PEG-TPP涂層是一個(gè)重要的界面，促進(jìn)MoS2-QD附著在腦組織內(nèi)小膠質(zhì)細(xì)胞的線粒體上。

我們目前的研究建立在這一范式的基礎(chǔ)上，深入研究了涂有DSPE-PEG-TPP的MoS2在保護(hù)腦組織內(nèi)蛋白質(zhì)二級(jí)結(jié)構(gòu)方面的復(fù)雜作用。此外，對(duì)DSPE-PEG-TPP-MoS2量子點(diǎn)治療對(duì)一系列生物標(biāo)志物的影響進(jìn)行了全面的探索。

在后續(xù)章節(jié)中可以進(jìn)一步闡明方法、詳細(xì)結(jié)果和深入分析，從而全面了解我們的研究。本研究揭示了MoS2-QD在保護(hù)腦組織蛋白質(zhì)二級(jí)結(jié)構(gòu)免受AD病因影響方面的作用。

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