抗體藥物偶聯(lián)物ADC-抗體與藥物連接位點(diǎn)的選擇

西安pg電子官方生物科技有限公司是科研材料供應(yīng)商，我們提供的產(chǎn)品性質(zhì)穩(wěn)定 、均有現(xiàn)貨，現(xiàn)我公司新上市一些小分子/ADC-抗體偶聯(lián)藥物/粒子液體可咨詢訂購(gòu)

抗體藥物偶聯(lián)物(antibody-drug conjugate，ADC)是通過(guò)一個(gè)化學(xué)鏈接將具有生物活性的小分子藥物連接到單抗上，單抗作為載體將小分子藥物靶向運(yùn)輸?shù)侥繕?biāo)細(xì)胞中，

抗體是一類具有特殊親和力的蛋白，利用其對(duì)靶細(xì)胞特異性的結(jié)合，有望作為藥物靶向遞送的載體，進(jìn)而增強(qiáng)藥物的選擇性。

抗體與藥物連接位點(diǎn)的選擇:

對(duì)抗體進(jìn)行藥物偶聯(lián)時(shí)，往往使用帶有特殊側(cè)鏈的氨基酸作為反應(yīng)位點(diǎn)。其中以半胱氨酸和賴氨酸為主。半胱氨酸在抗體中以二硫鍵的形式存在，因此需要對(duì)其進(jìn)行還原為自由巰基進(jìn)行下一步反應(yīng)。其中在抗體（IgG）鏈間有4對(duì)二硫鍵，比較容易被還原。而在抗體鏈內(nèi)，有12對(duì)二硫鍵，較難被還原。賴氨酸則分布于抗體結(jié)構(gòu)域，大約有86個(gè)賴氨酸殘基，其中有大約20個(gè)賴氨酸殘基可作為連接位點(diǎn)。除選擇氨基酸殘基外，選取保守糖基化的多糖作為修飾位點(diǎn)也是可行的。

西安pg電子官方生物供應(yīng)相關(guān)產(chǎn)品目錄：

cas:2128735-22-6 Amine-PEG2-Mal-PEG2-amine

cas:2128735-26-0 NH-Boc-PEG2-Mal-PEG2-NH-Boc

cas:2100306-51-0 t-butyl ester-PEG2-Mal-PEG2-t-butyl ester

cas:342818-95-5 Hydroxy-PEG2-N-methyl-PEG2-Hydroxy

cas:2055014-77-0 Acid-PEG4-N-methyl-PEG4-acid

cas:1835759-84-6 Alkyne-PEG2-N-methyl-PEG2-alkyne

cas:2182601-79-0 Methyl-PEG4-N-OH-PEG4-methyl

cas:1964503-35-2 Acid-PEG4-Biotin-PEG4-acid

cas:2100306-84-9 Amine-PEG4-Biotin-PEG4-acid

cas:2112731-59-4 N3-PEG2-Biotin-PEG3-acid

cas:2353409-72-8 DBCO-PEG4-Biotin-PEG4-NHS ester

cas:2055041-21-7 Acid-PEG4-S-PEG4-acid

cas:2055023-77-1 N3-PEG3-S-PEG3-N3

cas:2055041-24-0 N3-PEG3-S-PEG4-alkyne

cas:2055041-19-3 N3-PEG3-S-PEG4-t-butyl ester

cas:2173095-09-3 Methyl-PEG3-S-PEG2-hydroxy

cas:2055040-85-0 Methyl-PEG3-S-PEG4-alkyne

cas:2055040-96-3 Methyl-PEG3-S-PEG3-t-butyl ester

cas:2055041-20-6 Acid-PEG4-S-PEG4-alkyne

cas:2055041-17-1 Alkyne-PEG4-S-PEG4-alkyne

cas:2055041-18-2 Alkyne-PEG4-S-PEG4-t-butyl ester

cas:2055024-37-6 Acid-PEG4-Sulfone-PEG4-acid

cas:2055024-42-3 N3-PEG3-Sulfone-PEG4-acid

cas:2055024-45-6 N3-PEG3-Sulfone-PEG3-N3

cas:2055023-76-0 N3-PEG3-Sulfone-PEG4-t-butyl ester

cas:1919045-04-7 Methyl-PEG3-Sulfone-PEG3-acid

cas:1895922-76-5 Methyl-PEG3-Sulfone-PEG3-N3

cas:1919045-00-3 Methyl-PEG3-Sulfone-PEG2-hydroxy

cas:2055041-02-4 Methyl-PEG3-Sulfone-PEG4-alkyne

cas:2055041-00-2 Methyl-PEG3-Sulfone-PEG3-t-butyl ester

cas:2055024-41-2 Alkyne-PEG4-Sulfone-PEG4-acid

cas:2055041-02-4 Methyl-PEG3-Sulfone-PEG4-alkyne

cas:2055041-00-2 Methyl-PEG3-Sulfone-PEG3-t-butyl ester

cas:2055024-41-2 Alkyne-PEG4-Sulfone-PEG4-acid

cas:229977-57-5 MAC glucuronide linker-2

cas:791028-27-8 Amino-PEG2-C2-acid

cas:55750-61-3 AMAS

cas:1263044-56-9 MC-PEG2-C2-NHS ester

cas:185022-12-2 Aminooxy-PEG2-alcohol

cas:882847-34-9 Fmoc-NH-PEG6-CH2CH2COOH

cas:1061569-06-9 Ald-Ph-amido-PEG2

cas:132178-37-1 Propargyl-C1-NHS ester

cas:1807503-88-3 THP-SS-PEG1-Boc

cas:875770-32-4 Propargyl-PEG4-Tos

cas:2055014-98-5 Acid-PEG3-SS-PEG3-acid

cas:2182601-68-7 DBCO-PEG4-DBCO

cas:2110448-97-8 Gly-PEG3-amine

cas:1599440-15-9 MC-Gly-Gly-Phe

cas:1599472-25-9 Mal-PEG6-NHS ester

cas:331242-61-6 N-Boc-PEG6-alcohol

cas:1008402-79-6 Bis-PEG9-NHS ester

cas:876345-13-0 Boc-NH-PEG4-CH2COOH

cas:1002342-83-7 Ald-CH2-PEG3-azide

cas:1884578-00-0 Boc-Val-Ala-PAB-PNP

cas:1286837-77-1 trans-Sulfo-SMCC

cas:1309460-27-2 Ald-Ph-amido-PEG4-C2-acid

cas:2101206-86-2 SPDMV-sulfo

cas:1391914-41-2 Propargyl-PEG1-SS-alcohol

cas:1395786-30-7 DBCO-Maleimide

cas:67319-28-2 m-PEG3-CH2CH2COOH

cas:27425-92-9 m-PEG10-alcohol

cas:1257063-35-6 Azido-PEG4-C2-acid

cas:2101206-21-5 Ald-Ph-amido-PEG3-C2-Pfp ester

cas:1415328-95-8 NHPI-PEG4-C2-NHS ester

cas:1347760-82-0 Propargyl-PEG3-acid

cas:1353012-00-6 N3-PEG4-C2-Pfp ester

cas:1807518-67-7 Bromoacetamido-PEG4-acid

cas:635287-26-2 Fmoc-NH-PEG5-CH2COOH

cas:955094-26-5 Mal-amido-PEG2-NHS ester

cas:881895-59-6 6-O-2-Propyn-1-yl-D-galactose

cas:178685-33-1 Azide-PEG3-Tos

cas:1043426-13-6 Aminooxy-PEG2-azide

cas:2055041-39-7 Mal-PEG4-Val-Cit-PAB-OH

cas:1007215-94-2 Ald-Ph-amido-PEG3-C1-Boc

cas:1116086-09-9 Fmoc-Phe-Lys(Trt)-PAB-PNP

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