產(chǎn)品名稱：

活性氧Malabaricone B，63335-24-0

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

溫馨提示：僅用于科研，不能用于人體實驗！

Malabaricone B is a diarylnonanoid that has been found in Myristica and has diverse biological activities, including enzyme inhibitory, antimicrobial, anticancer, and antioxidant properties.1,2,3,4,5 It is an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 ?M, respectively, in fibroblast cell lysates).1 It is active against the bacteria S. aureus, B. subtilis, and S. durans (MIC = 1 ?g/ml for all) and three strains of the fungus C. albicans (MICs = 4-16 ?g/ml).2 It is cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 ?M, respectively) but not non-cancerous INT407, HEK293, or WI-38 cells.3 It increases the levels of intracellular reactive oxygen species (ROS) and induces apoptosis in A549 cells. It reduces the formation of thiobarbituric acid reactive substrates (TBARS) by 28.2% in rat liver mitochondria when used at a concentration of 2 ?g/ml but scavenges only 5% of 2,2-diphenyl-picrylhydrazyl (DPPH; Item No. 14805) radicals at 7 ?g/ml.4 Malabaricone B (10, 15, and 20 mg/kg) reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer.5

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編輯：XAQYBIO HAO，2023年3月15日。