文獻(xiàn)：mPEG-炔烴的二氧化碳吸附和熔融行為

鏈接：https://www.sciencedirect.com/science/article/abs/pii/S0896844621000218

作者：S. 洛佩斯，喬丹· 拉莫斯，JM García-Vargas，加西亞 山，JF 羅德里格斯，伊 ·格拉西亞

節(jié)選：

抽象的

了解 mPEG-炔烴和超臨界 CO 2 (scCO 2 ) 混合物的相行為和研究聚合物熔點(diǎn)的變化是確定適當(dāng)操作條件和開發(fā)高壓工藝的必要先決條件，以便獲得 mPEG-炔烴與藥物或蛋白質(zhì)的共軛物。在這項工作中，觀察到吸附 CO 2會導(dǎo)致 mPEG-炔烴的熔點(diǎn)溫度逐漸降低。使用改良的克勞修斯-克拉珀龍方程將獲得的熔化溫度關(guān)聯(lián)起來。使用采用靜態(tài)方法的可變體積觀察室確定CO 2在 mPEG-炔烴中的平衡吸附。這些實(shí)驗(yàn)是在 308 至 318 K 的溫度范圍內(nèi)以及 8–17 MPa 的壓力下進(jìn)行的。評估了亨利定律、雙模式、桑切斯-拉孔布狀態(tài)方程和啟發(fā)式模型的預(yù)測能力。

Abstract

The understanding of the phase behaviour of the mixture mPEG-alkyne and supercritical CO2 (scCO2) and the study of the variation of the polymer melting point are essential prerequisites in order to determine appropriate operating conditions and develop high pressure processes that allow the obtention of a conjugate mPEG-alkyne with a drug or a protein. In this work, it was observed a progressive decrease of the melting point temperature of mPEG-alkyne induced by the adsorption of CO2. The obtained melting temperatures were correlated using a modification of the Clausius Clapeyron equation. The equilibrium sorption of CO2 into mPEG-alkyne was determined with a variable-volume view cell employing a static method. These experiments were carried out in the temperature range 308 and 318 K, and at 8–17 MPa of pressure. The prediction capabilities of the models of Henry’s Law, Dual-Mode, Sanchez Lacombe Equation of State and Heuristic Model was evaluated.

西安pg電子官方生物提供相關(guān)產(chǎn)品：

DSPE-Cap-Biotin

DMG-PEG2000

C18-PEGn-OPSS

DSPE-PEG-NTA-NI

DPPE-PEG-NH2

DSPE-PEG-COOH（二硬脂�；�磷脂酰乙醇胺-聚乙二醇-羧基)

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