ADC抗體藥物偶聯(lián)細(xì)胞*素藥物-DBCO點(diǎn)擊反應(yīng)SET?

西安pg電子官方生物提供的DBCO點(diǎn)擊反應(yīng)SET?是一種可以篩選抗體藥物偶聯(lián)物工具。SET?產(chǎn)品線包括很多已驗(yàn)證的連接子-*素，DBCO點(diǎn)擊反應(yīng)SET?只需按照產(chǎn)品說明書上提供的溶解方案，即可使用SET?。SET?不僅易于使用，更重要的是可以減少實(shí)驗(yàn)過程中暴露*素的風(fēng)險(xiǎn)。

點(diǎn)擊化學(xué)(Click chemistry)，又譯為"鏈接化學(xué)"、"速配接合組合式化學(xué).二苯并環(huán)辛炔（ADIBO，DBCO）是用于應(yīng)變促進(jìn)的炔疊氮化物環(huán)加成（spAAC）（一種無銅Click化學(xué)反應(yīng)）的反應(yīng)性的環(huán)炔。

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二：原理

點(diǎn)擊化學(xué)反應(yīng)主要有4 種類型

1.環(huán)加成反應(yīng)

2.親核開環(huán)反應(yīng)

3.非醇醛的羰基化學(xué)

4.碳碳多鍵的加成反應(yīng)

三：反應(yīng)特征

1. 反應(yīng)原料容易得到

2. 對(duì)于氧氣、水不敏感

3. 產(chǎn)率相對(duì)較高

4. 產(chǎn)物的立體選擇性好

產(chǎn)品目錄：

點(diǎn)擊反應(yīng)SET?  

DBCO-PEG4-vc-PAB-MMAE

DBCO-PEG4-MMAF

DBCO-PEG4-Ahx-DM1

DBCO-PEG4-vc-PAB-Duocarmycin SA

DBCO-PEG4-vc-PAB-(PEG2)-Duocarmycin SA

DBCO-PEG4-VA-PBD

DBCO-PEG4-vc-PAB-MMAF

DBCO-PEG4-vc-PAB-MMAD

DBCO-PEG4-vc-PAB-Duocarmycin TM

DBCO-PEG4-vc-PAB-(PEG2)-Duocarmycin TM

DBCO-PEG4-vc-PAB-Duocarmycin DM

DBCO-PEG4-vc-PAB-(PEG2)-Duocarmycin DM

DBCO-PEG4-VC-PAB-DMAE-PNU159682

DBCO-PEG4-DMAE-PNU159682

DBCO-PEG4-GGFG-DX8951

DBCO-PEG4-vc-PAB-Ahx-DM1

DBCO-PEG8-VA-PAB-SG3199 200 nmol

其它反應(yīng)SET?產(chǎn)品

Boc-Val-Dil-Dap-OH

Boc-Val-Dil-Dap-Phe-Ome

Boc-Val-Dil-Dap-Doe

Boc-Nme-Val-Val-Dil-Dap-OH

Tubulysin IM-1

Tubulysin IM-2

Tubulysin IM-3

Duocarmycin SA

Duocarmycin TM

Duocarmycin MA

Duocarmycin DM

Nemorubicin

17-AAG

Actinomycin D

Actinomycin X2

17-AEP-GA

Aeroplysinin 1

Aeruginosin 865

Agrochelin A

Agrochelin B

17-AH-Geldanamycin

gamma-Amanitin

Ansatrienin B

Aphidicolin

Apoptolidin

AZD4547, Free Base

AZD8055, Free Base

Bafilomycin A1

Chaetocin

Chaetoglobosin

Chaetoglobosin C13

Chlamydocin

Mitomycin C

DC44SMe

SGD-1882

Camptothecin

SN-38

Mertansine

Aldoxorubicin

Auristatin F

SJG-136

D8-MMAF hydrochloride

DRF-1042

Auristatin E

MMAF-OMe

DM4-SMe

DC1SMe

Cyclooctyne-O-NHS ester

Ansamitocin P 3'

MMAF sodium

DC41SMe

Duocarmycin A

DC41

DC1

DM3

(+)-CBI-CDPI1

DM3-SMe

DMEA-PNU-159682

(S)-Seco-Duocarmycin SA

DC0-NH2

(+)-CBI-CDPI2

Duocarmycin GA

Duocarmycin Analog

Duocarmycin MB

Py-MPB-amino-C3-PBD

Cyclooctyne-O-PFP ester

DC4SMe

β-Amanitin

Seco-Duocarmycin TM

Aniline-MPB-amino-C3-PBD

N-Me-L-Ala-maytansinol

DC10SMe

Maytansinoid DM4

N-Boc-Val-Dil-Dap-Doe

Dimethyl-SGD-1882

Top1 inhibitor 1

D8-MMAF

Azonafide-PEABA

17-DMAP-GA

Campathecin

D8-MMAE

PNU-159682 carboxylic acid

DL-Dithiothreitol/DTT

DL-Dithiothreitol/DTT - biotech grade