久精品免费观看国产33,精品国产电影在线看免,在线观看aⅴ免费,久久99久久久一本精品

        • 您當(dāng)前所在位置:首頁 > 資訊信息 > 新品上市
          DSPE-PEG-COOH在PLGA-脂質(zhì)納米粒子中用于葉酸靶向藥物輸送的應(yīng)用
          發(fā)布時間:2025-07-01     作者:zyl   分享到:

          文獻:Lipid-Polymer Nanoparticles for Folate-Receptor Targeting Delivery of Doxorubicin

          作者:Zheng, Mingbin; Gong, Ping; Zheng, Cuifang; Zhao, Pengfei; Luo, Zhenyu; Ma, Yifan; Cai, Lintao

          文獻鏈接:https://www.ingentaconnect.com/contentone/asp/jnn/2015/00000015/00000007/art00004

          摘要:

          A biocompatible PLGA-lipid hybrid nanoparticles (NPs) was developed for targeted delivery of anticancer drugs with doxorubicin (DOX). The hydrodynamic diameter and zeta potential of DOX-loaded PLGA-lipid NPs (DNPs) were affected by the mass ratio of Lipid/PLGA or DSPE-PEG-COOH/Lecithin. At the 1:20 drug/polymer mass ratio, the mean hydrodynamic diameter of DNPs was the lowest (99.2±1.83 nm) and the NPs presented the encapsulation efficiency of DOX with 42.69±1.30%. Due to the folate-receptor mediated endocytosis, the PLGA-lipid NPs with folic acid (FA) targeting ligand showed significant higher uptake by folate-receptor-positive MCF-7 cells as compared to PLGA-lipid NPs without folate. Confocal microscopic observation and flow cytometry analysis also supported the enhanced cellular uptake of the FA-targeted NPs. The results indicated that the FA-targeted DNPs exhibited higher cytotoxicity in MCF-7 cells compared with non-targeted NPs. The lipid-polymer nanoparticles provide a solution of biocompatible nanocarrier for cancer targeting therapy.

          Gso6k8KkkM7RycDaQNRv.png

          開發(fā)了一種生物相容性PLGA-脂質(zhì)雜化納米粒子(NP),用于與阿霉素(DOX)靶向遞送藥物。

          DOX負(fù)載的PLGA脂質(zhì)NP(DNPs)的流體動力學(xué)直徑和ζ電位受到脂質(zhì)/PLGA或DSPE-PEG-COOH/卵磷脂質(zhì)量比的影響。

          在1:20的藥物/聚合物質(zhì)量比下,DNP的平均流體動力學(xué)直徑低(99.2±1.83 nm),NP的DOX包封效率為42.69±1.30%。

          由于葉酸受體介導(dǎo)的內(nèi)吞作用,與不含葉酸的PLGA脂質(zhì)NP相比,具有葉酸(FA)靶向配體的PLGA脂NP顯示出葉酸受體陽性MCF-7細(xì)胞對葉酸的攝取明顯更高。

          共聚焦顯微鏡觀察和流式細(xì)胞術(shù)分析也支持FA靶向NP的細(xì)胞攝取增強。

          結(jié)果表明,與非靶向NP相比,F(xiàn)A靶向DNPs在MCF-7細(xì)胞中表現(xiàn)出更高的細(xì)胞毒性。脂質(zhì)聚合物納米顆粒為癌癥靶向治療提供了生物相容性納米載體的解決方案。

          相關(guān)推薦:

          DSPE-PEG-RGD

          DSPE-PEG-SC

          DSPE-PEG-SCM

          DSPE-PEG-SG

          DSPE-PEG-SH

          DSPE-PEG-Silane

          DSPE-PEG-SP2-AA

          DSPE-PEG-SS

          DSPE-PEG-TCO

          DSPE-PEG-Tetrazine

          DSPE-PEG-TMS

          DSPE-PEG-TPP

          以上文章內(nèi)容來源各類期刊或文獻,如有侵權(quán)請聯(lián)系我們刪除!

          庫存查詢