文獻(xiàn)：PLGA–LECITHIN–PEG CORE-SHELL NANOPARTICLES FOR CANCER TARGETED THERAPY

文獻(xiàn)鏈接：https://www.worldscientific.com/doi/abs/10.1142/S1793984411000359

作者：MINGBIN ZHENG, PING GONG, DONGXUE JIA, CUIFANG ZHENG, YIFAN MA, and LINTAO CAI

We reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG-COOH/lecithin, DSPE-PEG-COOH/DSPE-PEG-NH2 mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA–lecithin–PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.

多功能聚乳酸-羥基乙酸共聚物（PLGA）-卵磷脂-聚乙二醇（PEG）核殼納米粒子（NP）的開(kāi)發(fā)，該納米粒子結(jié)合了脂質(zhì)體和聚合物NP的有益特性，用于藥物的輸送。

通過(guò)各種配方參數(shù)，如脂質(zhì)/聚合物、1,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺（DSPE）-PEG-COH/卵磷脂、DSPE-PEG-COOH/DSPE-PEG-NH2質(zhì)量比和DSPE-PEG末端基團(tuán)的修飾，粒徑、表面電荷和表面官能團(tuán)很容易以高度可重復(fù)的方式進(jìn)行調(diào)節(jié)。

我們將模型化療藥物親水性順鉑（DDP）或疏水性DDP前藥封裝在NP中，并顯示出高封裝效率、優(yōu)異的穩(wěn)定性、對(duì)MCF-7細(xì)胞的特異性FA靶向識(shí)別，具有過(guò)FA受體表達(dá)和相當(dāng)?shù)募?xì)胞毒性。這種PLGA–卵磷脂–PEG核殼納米粒子（NP）被證明是一種很有前途的癌癥靶向治療藥物遞送納米載體。

相關(guān)推薦：

DSPE-PEG-Cy7

DSPE-PEG-cRGD

DPPE-PEG-cRGD

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DOPE-PEG-cRGD

DPPE-PEG-RGD

DMPE-PEG-RGD

DOPE-PEG-RGD

4-Arm PEG-DSPE

C12-PEG-COOH

C18-PEG-COOH

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