文獻(xiàn)：脂質(zhì)功能化的金納米棒與直接插入線粒體的靶向配體用于**的協(xié)同光熱化療

鏈接：https://www.sciencedirect.com/science/article/abs/pii/S0939641123000425

作者：米 王，莫 張，胡曉曉 ，王文麗 ，張耀 ，張麗娜 ，王靜

摘要：

線粒體靶向*策略有望實(shí)現(xiàn)更有效、更精準(zhǔn)的癌癥*。光熱療法作為一種非侵入性癌癥*方法已被廣泛研究。對于一體化納米載體介導(dǎo)的藥物遞送平臺而言，如何在不損害其他優(yōu)點(diǎn)的情況下增強(qiáng)其中一項(xiàng)特性仍然是一個(gè)挑戰(zhàn)。在此，我們提出了一種線粒體靶向光熱化療一體化納米平臺，該平臺包含脂質(zhì)功能化的金納米棒 (AuNR) 和可直接插入線粒體的靶向配體，用于協(xié)同增強(qiáng)**。

首先，利用巰基和金的特殊親和力，用 DSPE-PEG-SH 修飾 AuNR。然后，將具有線粒體靶向特性的 DSPE-PEG-DOX 直接插入 DSPE-PEG-SH 層。同時(shí)，將紫杉醇 (PTX) 負(fù)載于脂質(zhì)層的疏水區(qū)。與引入額外的線粒體靶向分子不同，我們將兩親性DSPE-PEG-DOX引入到圍繞金納米棒修飾的DSPE-PEG-SH層中，在簡單的金納米棒-脂質(zhì)-DOX/紫杉醇平臺中同時(shí)實(shí)現(xiàn)線粒體靶向、光熱和雙載藥，從而有效增強(qiáng)線粒體中活性氧（ROS）的產(chǎn)生，并達(dá)到*的**效果。基于脂質(zhì)功能化的金納米棒構(gòu)建的納米平臺具有良好的生物相容性，將線粒體靶向的DSPE-PEG-DOX與線粒體作用的紫杉醇和光熱療法（PTT）協(xié)同作用，為細(xì)胞器靶向的PTT聯(lián)合化療以提高療效提供了一種可行的策略。

Abstract

Mitochondria targeting therapeutic strategies are promising for more effective and precise cancer therapy. Photothermal therapy are extensively studied as noninvasive cancer treatment. With regards to all-in-one nanocarrier-mediated drug delivery platform, it is still a challenge to enhance one of the features but not compromise other merits. Herein, we present a mitochondrial targeting photothermal-chemotherapy all-in-one nanoplatform involving lipid-functionalized gold nanorods (AuNR) with plug-to-direct mitochondria targeting ligand for synergetic enhanced tumor therapy. Firstly, AuNR were modified by DSPE-PEG-SH owing to the special affinity of sulfhydryl group and gold. And then, DSPE-PEG-DOX with mitochondrial targeting character was directly inserted into DSPE-PEG-SH layer. Meanwhile, paclitaxel (PTX) was loaded in hydrophobic region of the lipid layer. Quite different from introducing additional mitochondrial targeting molecules, we incorporated amphiphilic DSPE-PEG-DOX into a DSPE-PEG-SH layer modified around AuNR to achieve both mitochondrial targeting, photothermal and dual drug loading in a simple AuNR-lipid-DOX/PTX platform, in the case that efficiently enhanced production of reactive oxygen species (ROS) in mitochondria and excellent anti-tumor efficacy were achieved. With good biocompatibility, the constructed nanoplatform based on lipid-functionalized AuNR synergistically combined mitochondrial targeted DSPE-PEG-DOX with mitochondrial-acted PTX and photothermal therapy (PTT), which provided a feasible strategy for organelle-targeted combination PTT-chemotherapy to improve therapeutic effects.

西安pg電子官方生物提供相關(guān)產(chǎn)品：

MMPs-PEG-DSPE

WSW(WSWGPYS)-PEG-DSPE

LyP-1-PEG-DSPE

VIP-PEG-DSPE

CREKA-PEG-DSPE

Asp8-PEG-DSPE

WYRGRL-PEG-DSPE

CTP-PEG-DSPE

CMP-PEG-DSPE

SHp-PEG-DSPE

CGKRK-PEG-DSPE

Xpeptide-PEG-DSPE

Asp6-PEG-DSPE

以上文章內(nèi)容來源各類期刊或文獻(xiàn)，如有侵權(quán)請聯(lián)系我們刪除！